[BrianG]

Nope. You'll have to re-insert the red wire to program the ESC. To make future programming easier, there are a couple options:

1: Leave the red wire in the throttle cable, but then get (or make) a very short servo extension wire with the red wire removed from that.

Or

2: Solder another set of servo connections on the existing throttle cable, effectively making a Y cable. Remove the red wire from one of the legs and use that to the receiver. Keep the red wire in the other leg and use that only for programming.

Personally, I like option 2. Adding an extension is obviously much easier to do/undo, but the added connections may cause an issue and be harder to stuff the extra wire somewhere when the added length is not needed.