We just run em over with our cars up here all the time and the little suckers still breed so fast, we can't put a dent in the population. They harass dogs and cats constantly, ruins bird houses/feeders, chew/claw rooftops, shingles, duct work, make nests in rain gutters, poop all over the place. Worst part is there not even a native species to this area.

I always enjoyed this method of squirrel control


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