Alot of people on this forum run some really powerfull setups and they require some extreme mods to make the rest of the drivetrain hold up. If you run a mild to mid brushless setup you won't have that much to worry about.
The steel idler gear in the tranny is an absolute
must, but only $15 so not that big a deal. If you get one and install it in 2nd gear (you won't use first anymore)you will have a pretty durable tranny.
http://www.rc-monster.com/proddetail...rod=RCM03idler
The 2nd must upgrade is the CVDs for the tranny and the wheels. This is probably the most expensive additional upgrade that you should do right away. (In my opinion) The plastic sliders on the e-maxx just don't hold up to brushless power. When you do this don't just get the cheapos off ebay. At least get the MIP (UE is better still) or you will just wind up buying a 2nd set again in the not to distant future.
The diffs will eventually go, but the stockers will last quite a while(depending on your driving stlye). When/If the diffs go, just get some alluminum diff cups and the robinson racing pinion and ring gears in them and you will be fine. I have found that it is generally the rear that goes and the front lasts pretty well. (I still run stock diffs in my maxx. They are cheap on ebay and I just have an extra or 2 laying around to change out when I need to. Not very often)
Slipper clutch is another item that people try to ''get away with'' the stock unit. They wind up just cranking it down and locking it up or it will just melt. Locking down the slipper is probably one of the biggest reasons that other drivtrain componenets fail. The slipper is designed to absorbe the harsh shocks in the drivetrain and thus preserve the rest of the parts. I would recomend an upgrade here as well.
It takes a little more than just a motor and esc to get a good reliable brushless setup, but its well worth it. Even the original Novak HV recomends the Steel Idler gear and the upgraded slipper clutch.
For what you said you are looking for, the new Novak-HV 4.5 might be a good option. Its pretty much plug and play. they give you complete setup instructions and even a list of recomended upgrades. And from what I have heard , its pretty fast. Should get you over 40 easy.
Just my $0.02.