It wont make any difference as such- gears are gears, whether they are connected by a chain/belt, or mesh against each other. I would use BrianG's calculator, or draw out your own diagram, and work out the ratios from there.
That's just it, if i was doing something completely different (robot wheelchair in this case) how do i figure up the final ratio, i really have no idea how to figure this. I would like a ratio of at least 7.14:1. What number of teeth on each sprocket would it take to get this in gearbox form (would be using 4 sprockets) because i'm limited on space and smaller sprockets are cheaper.