I've got the 4.6l in my 9000# handicapped van and it is a strong motor. I've got 183,000 miles on it and I plan on making it to 300,000. It run and starts like new.
The key to success with any vehicle is meticulous maintenance.
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It's "Dr. _paralyzed_" actually. Not like with a PhD, but Doctor like in Dr. Pepper.