There are soooo many factors that affect runtime, that to be honest, a good guess would be as accurate as any calculation. The main thing that affects runtime is driving style, and theres no real way of integrating this into a calculation, seeing as everyone drives in a different style.
just do a testrun, it saves you a few days of calculating.
Also, once you've got a rough idea of the runtime you get with your system, if you change to different capacity batteries you should be able to get a fairly accurate idea of runtimes. ie, If you got 15 minutes with 3000mah packs, you should get 30 minutes with 6000mah packs.