Running Packs in series or parrallel

[starscream]

Hmm, from my perspective example B and C, from the original question, are identical as a saddle pack would be 2 4S 4000mAh packs. In regards to 4 2S packs, that would be very impractical, hard to manage, and would be a last resort imo. Using more than two packs on a car would be an ineficient use of resources.
I don't know too many folks that are concerned about keeping Lipo cells balanced during discharge. As long as you are using a low voltage cutoff and a Balancing Charger, a 1P configuration will always be ideal. Thats my 2 cents anyway