I can almost anything, and have quite a few things that aren't on the website (it takes abit of time to load new items to the site, especially with pictures).
I would still run the 22 pinion on the 54 tooth spur(I don't have this currently in stock, but I can get them). The Strobe slipper is an excellent upgrade as well, as it allows power delivery tuning.
Compared to stock tires, yes. They are only about 4.75" tall and a lot lighter. You can afford to gear for a bit more speed due to the decrease in rotating mass.
Yep. I have stable maxx wheels, white and yellow dish wheels(standard and 23mm hex), chrome proline velos, etc., along with many different tires and 40 series wheels and tires as well!